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Pemphigus

Image Description
pemphigus

Pemphigus. Collapsed vesicles and bullae and crusted ulcers are present on the face.

pemphigus

Pemphigus. Low-power photomicrograph shows a vesicle within the stratified squamous epithelium. Epithelial cells are present along the base of the vesicle. Hematoxylin and eosin stain.

pemphigus

Pemphigus. Low-power photomicrograph shows a vesicle within the stratified squamous epithelium. Epithelial cells are present along the base of the vesicle. Hematoxylin and eosin stain.

pemphigus

Pemphigus. Medium power photomicrograph of direct immunofluorescence preparation. There is staining for antibodies in the intercellular spaces of the stratified squamous epithelium. This indicates that antibody is being produced against the intercellular material of the epithelium.

pemphigus

Pemphigus: Low power microscopic image showing intraepithelial splitting.

pemphigus

Pemphigus: High power microscopic image showing loss of cohesion of keratinocytes (acantholysis) leading to intraepithelial vesicle formation. Note that the basal and lower spinous cell layers are intact.