Dr. Butali joined the College of Dentistry in 2013 after completing his postdoctoral fellowship in craniofacial genetics at the University of Iowa.
Dr. Butali's primary responsibility is conducting research -- initiating projects, study design, and the direction of genome-wide studies for craniofacial anomalies and subclinical cleft phenotypes in the African population. He is also responsible for the design and coordination of research into the genetic causes of aggressive periodontitis and preterm births in Africa.
Dr. Butali's teaching responsibilities include seminars, conferences for undergraduate dental students, and students in the oral science graduate programs.
Dr. Butali directs the African Craniofacial Anomalies Network, a collaboration between scientists in Ghana, Ethiopia, Kenya, Nigeria, and Rwanda. His research, "Genetic Studies of Non-syndromic Clefts in Populations of African Descent," is currently funded through a K99/R00 award from the National Institute for Dental and Craniofacial Research. His studies use a variety of techniques and approaches, including next generation sequencing approaches. He is also involved in the investigation of subclinical phenotypes for orofacial clefts as well as examining the role of micronutrients in oral clefts prevention. Other interests include genetics of aggressive periodontitis and genetics of preterm births in the African population. He is currently collaborating with researchers in Nigeria, Ghana, Ethiopia, South Africa, Rwanda, Kenya, Dundee (Scotland), Seattle (WA), Pittsburgh (PA), and Puerto Rico.
1: Jia Z, Leslie EJ, Cooper ME, Butali A, Standley J, Rigdon J, Suzuki S, Gongorjav A, Shonkhuuz TE, Natsume N, Shi B, Marazita ML, Murray JC. Replication of 13q31.1 association in nonsyndromic cleft lip with cleft palate in Europeans. Am J Med Genet A. 2015 May;167(5):1054-60. doi: 10.1002/ajmg.a.36912. Epub 2015 Mar 18. PubMed PMID: 25786657; PubMed Central PMCID: PMC4402974.
2: Butali A, Mossey P, Adeyemo W, Eshete M, Gaines L, Braimah R, Aregbesola B, Rigdon J, Emeka C, Olutayo J, Ogunlewe O, Ladeinde A, Abate F, Hailu T, Mohammed I, Gravem P, Deribew M, Gesses M, Adeyemo A, Marazita M, Murray J. Rare functional variants in genome-wide association identified candidate genes for nonsyndromic clefts in the African population. Am J Med Genet A. 2014 Oct;164A(10):2567-71. doi: 10.1002/ajmg.a.36691. Epub 2014 Jul 31. PubMed PMID: 25081408; PubMed Central PMCID: PMC4169286.
3: Butali A, Mossey PA, Adeyemo WL, Eshete MA, Gaines LA, Even D, Braimah RO, Aregbesola BS, Rigdon JV, Emeka CI, James O, Ogunlewe MO, Ladeinde AL, Abate F, Hailu T, Mohammed I, Gravem PE, Deribew M, Gesses M, Adeyemo AA, Murray JC. Novel IRF6 mutations in families with Van Der Woude syndrome and popliteal pterygium syndrome from sub-Saharan Africa. Mol Genet Genomic Med. 2014 May;2(3):254-60. doi: 10.1002/mgg3.66. Epub 2014 Jan 27. PubMed PMID: 24936515; PubMed Central PMCID: PMC4049366.
4: Butali A, Little J, Chevrier C, Cordier S, Steegers-Theunissen R, Jugessur A, Oladugba B, Mossey PA. Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis. Birth Defects Res A Clin Mol Teratol. 2013 Aug;97(8):509-14. doi: 10.1002/bdra.23133. Epub 2013 May 13. PubMed PMID: 23670871; PubMed Central PMCID: PMC3745533.
5: Butali A, Suzuki S, Cooper ME, Mansilla AM, Cuenco K, Leslie EJ, Suzuki Y, Niimi T, Yamamoto M, Ayanga G, Erkhembaatar T, Furukawa H, Fujiwawa K, Imura H, Petrin AL, Natsume N, Beaty TH, Marazita ML, Murray JC. Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P). Am J Med Genet A. 2013 May;161A(5):965-72. doi: 10.1002/ajmg.a.35749. Epub 2013 Mar 5. PubMed PMID: 23463464; PubMed Central PMCID: PMC3634899.
6: Butali A, Adeyemo WL, Akinshipo AO, Fashina A, Savage KO. Use of information and communication technology among dental students and registrars at the faculty of dental sciences, University of Lagos. Niger J Clin Pract. 2011 Oct-Dec;14(4):467-72. doi: 10.4103/1119-3077.91758. PubMed PMID: 22248952.
7: Butali A, Adeyemo WL. An overview of cleft care in Nigeria. Niger Postgrad Med J. 2011 Jun;18(2):151-3. Review. PubMed PMID: 21670785.
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Dr. Butali is a member of the Challenge Team 9, Global Initiative of the American Cleft Palate Association; the Society of Craniofacial Geneticists; the American Society for Human Genetics; the International Genetic Epidemiology Society; the American Association for Dental Research, the International Association for Dental Research. and the Pan African Association for Cleft Lip and Palate.