Lina Moreno-Uribe

Lina Moreno-Uribe
Lina Moreno-Uribe, D.D.S., Ph.D.
Associate Professor, Department of Orthodontics
Expertise: 
Identifying genes that affect growth of the human face
Education: 
DDS, Instituto de Ciencias de la Salud CES, 1991
Certificate, Orthodontics, Universidad de Antioquia, 1995
PhD, Oral Sciences, University of Iowa, 2005
Certificate, Orthodontics, University of Iowa, 2008
To Make An Appointment: 
319-335-7287
Brief Professional Resume: 

Dr. Moreno-Uribe joined the College of Dentistry in 2008 as an assistant professor in both the Department of Orthodontics and the Iowa Institute for Oral Health Research. She is currently an associate professor.

Research Activities: 

Dr. Moreno-Uribe's research interest focuses on performing a genome-wide search for genes that affect growth of the human face using whole genome association methods and the latest technology for facial imaging. She wants to identify genotype-phenotype correlations that contribute to the development of an individual's maxillo-mandibular complex. This knowledge will likely result in development of an individual's maxillo-mandibular complex. This knowledge will also likely result in the development of novel orthodontic and maxillofacial therapies that will benefit our patients.

Publications: 

1: Moreno Uribe LM, Ray A, Blanchette DR, Dawson DV, Southard TE. Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion. Orthod Craniofacial Res. 2015; 18 Suppl 1:100-8. NIHMSID: NIHMS659573 PubMed, PMID 25865538, PMCID: PMC4396710.

2: Moreno Uribe LM, Miller SF. Genetics of the dentofacial variation in human malocclusion. Orthod Craniofac Res. 2015; 18 Suppl 1:91-9. PMID: 25865537.

3: Lidral AC, Liu H, Bullard SA, Bonde G, Machida J, et al. A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1. Hum Mol Genet. 2015; PMID: 25652407.

4: Miller SF, Weinberg SM, Nidey NL, Defay DK, Marazita ML, et al. Exploratory genotype-phenotype correlations of facial form and asymmetry in unaffected relatives of children with non-syndromic cleft lip and/or palate. J Anat. 2014;224(6):688-709. NIHMSID: NIHMS600651, PMID: 24738728, PMCID: PMC4025896.

5: Smith BJ, Nidey N, Miller SF, Moreno Uribe LM, Baum CL, et al. Digital imaging analysis to assess scar phenotype. Wound Repair Regen: official publication of the Wound Healing Society the European Tissue Repair Society. 2014; 22(2):228-338. NIHMSID: NIHMS680788, PMID: 24635173, PMCID: PMC4411947.

6: Moreno Uribe LM, Howe SC, Kummet C, Vela KC, Dawson DV, et al. Phenotypic diversity in white adults with moderate to severe Class II malocclusion. Am J Orthod Dentofac Orthop. 2014; 145(3):305-16. NIHMSID: NIHMS567877, PMID: 24582022, PMCID: PMC4007218.

7: Wehby GL, Moreno LM. Oral clefts and wellbeing: a lifelong perspective and an agenda for comparative effectiveness research. J Comp Eff Res. 2014 Jan;3(1):23-8. doi: 10.2217/cer.13.80. PubMed PMID: 24345254.

8: Moreno Uribe LM, Vela KC, Kummet C, Dawson DV, Southard TE. Phenotypic diversity in white adults with moderate to severe Class III malocclusion. Am J Orthod Dentofac Orthop. 2013; 144(1):32-42. NIHMSID: NIHMS556025, PMID: 23810043, PMCID:  PMC3964133.

9: Katkar RA, Kummet C, Dawson D, Moreno Uribe L, Allareddy V, et al. Comparison of observer reliability of three-dimensional cephalometric landmark identification on subject images from Galileos and i-CAT cone beam CT. Dentomaxillofac Radiol. 2013;42(9):20130059. PMID: 2383319, PMCID: PMC382023.

10: Camargo M, Rivera D, Moreno L, Lidral AC, Harper U, et al. GWAS reveals new recessive loci associated with non-syndromic facial clefting. Eur J Med Genet. 2012; 55(10):510-4. NIHMSID: NIHMS407263, PMID: 22750566, PMCID: PMC3521569.

11: Letra A, Fakhouri W, Fonseca RF, Menezes R, Kempa I, et al. Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate. PloS one. 2012; 7(9):e45441. PMID: 23029012, PMCID: PMC3447924.

12: Wehby G, Jugessur A, Murray JC, Moreno L, Wilcox A, Lie RT. Genes as instruments for studying risk behavior effects: an application to maternal smoking and orofacial clefts. Health Serv Outcomes Res Methodol. 2011 Jul 1;11(1-2):54-78. PubMed PMID: 22102793; PubMed Central PMCID: PMC3216039.

13: Wehby GL, Fletcher JM, Lehrer SF, Moreno LM, Murray JC, Wilcox A, Lie RT. A genetic instrumental variables analysis of the effects of prenatal smoking on birth weight: evidence from two samples. Biodemography Soc Biol. 2011;57(1):3-32. PubMed PMID: 21845925, PMCID: PMC3256988.

14: Beaty TH, Murray JC, Marazita ML, Munger RG, Ruczinski I, et al. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nature Genet. 2010;42(6):525-9. PMID: 20436369, PMCID: PMC2941216.

15: Moreno LM, Mansilla MA, Bullard SA, Cooper ME, Busch TD, Machida J, Johnson MK, Brauer D, Krahn K, Daack-Hirsch S, L'heureux J, Valencia-Ramirez C, Rivera D, López AM, Moreno MA, Hing A, Lammer EJ, Jones M, Christensen K, Lie RT, Jugessur A, Wilcox AJ, Chines P, Pugh E, Doheny K, Arcos-Burgos M, Marazita ML, Murray JC, Lidral AC. FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. Hum Mol Genet. 2009 Dec 15;18(24):4879-96. doi: 10.1093/hmg/ddp444. Epub 2009 Sep 24. PMID: 19779022, PMCID: PMC2778374.

16: Lidral AC, Moreno LM, Bullard SA. Genetic Factors and Orofacial Clefting. Semin Orthod. 2008 Jun;14(2):103-114.  PMID: 19492008; PMCID: PMC2598422.

17: Chiquet BT, Lidral AC, Stal S, Mulliken JB, Moreno LM, et al. CRISPLD2: a novel NSCLP candidate gene. Human molecular genetics. 2007;16(18):2241-8. MIHMSID: NIHMS133941, PMID: 17616516, PMCID: PMC3755375.

18: Modesto A, Moreno LM, Krahn K, King S, Lidral AC. MSX1 and orofacial clefting with and without tooth agenesis. J Dent Res. 2006 Jun;85(6):542-6. PubMed PMID: 16723652; PubMed Central PMCID: PMC2241923.

19: Lidral AC, Moreno LM. Progress toward discerning the genetics of cleft lip. Curr Opin Pediatr. 2005 Dec;17(6):731-9. Review. PubMed PMID: 16282779; PubMed Central PMCID: PMC2752353.

20: Zucchero TM, Cooper ME, Maher BS, Daack-Hirsch S, Nepomuceno B, Ribeiro L, Caprau D, Christensen K, Suzuki Y, Machida J, Natsume N, Yoshiura K, Vieira AR, Orioli IM, Castilla EE, Moreno L, Arcos-Burgos M, Lidral AC, Field LL, Liu YE, Ray A, Goldstein TH, Schultz RE, Shi M, Johnson MK, Kondo S, Schutte BC, Marazita ML, Murray JC. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. N Engl J Med. 2004 Aug 19;351(8):769-80. PMID: 15317890.

21: Moreno LM, Arcos-Burgos M, Marazita ML, Krahn K, Maher BS, Cooper ME, Valencia-Ramirez CR, Lidral AC. Genetic analysis of candidate loci in non-syndromic cleft lip families from Antioquia-Colombia and Ohio. Am J Med Genet A. 2004 Mar 1;125A(2):135-44. PMID: 14981713.

22. Marazita ML, Murray JC, Lidral AC, Arcos-Burgos M, Cooper ME, et al. Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35. Am J Hum Genet. 2004;75(2):161-73. PMID: 15185170, PMCID: PMC1216052.

23: Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe Y, Howard E, de Lima RL, Daack-Hirsch S, Sander A, McDonald-McGinn DM, Zackai EH, Lammer EJ, Aylsworth AS, Ardinger HH, Lidral AC, Pober BR, Moreno L, Arcos-Burgos M, Valencia C, Houdayer C, Bahuau M, Moretti-Ferreira D, Richieri-Costa A, Dixon MJ, Murray JC. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nat Genet. 2002 Oct;32(2):285-9. Epub 2002 Sep 3. PubMed PMID: 12219090; PubMed Central PMCID: PMC3169431.

PubMed Publications: 

Click here to perform an automatic PubMed search of Dr. Moreno-Uribe's publications.