Kim A. Brogden

Kim A. Brogden
Kim A. Brogden, Ph.D.
Director, Iowa Institute for Oral Health Research
Education: 
BS, Iowa State University, 1975
MS, Iowa State University, 1977
PhD, Iowa State University, 1981
Email Address: 
kim-brogden@uiowa.edu
Brief Professional Resume: 

Dr. Brogden joined the College of Dentistry in 2004. He is director of the Iowa Institute for Oral Health Research and a professor in the Department of Periodontics.

Nov 2012-present Director, Iowa Institute for Oral Health Research
2004-present Professor, Department of Periodontics
Jul 2017-Jan 2018 Interim DEO, Department of Periodontics
Oct 2014-Jan 2015 Interim Associate Dean for Research
2003-2004 Research Program Representative, USDA, ARS, NADC, Ames, IA
1999-2004 Research Leader (Department Head), Respiratory Diseases, USDA, ARS, NADC, Ames, IA
1999-2004 Collaborating Professor, Cellular and Molecular Pathology specialty of Veterinary Pathology, Iowa State University, Ames, IA
2001-2001 National Program Leader for Animal Health, National Program Staff, USD, ARS, Beltsville, MD
1981-1999 Microbiologist, USDA, ARS, NADC, Ames, IA

 

Research Activities: 

Dr. Brogden's research interests focus on the following areas.

  • Predictive computational simulation models. Working with collaborators to develop predictive computational simulation models of immune cells, cancer cells, and co-cultured cells to predict extracellular and cellular biomarker readouts (including immunosuppressive immune checkpoint biomarkers) in an automated high-throughput system - characteristics useful for predicting immunotherapy responses important to controlling a variety of cancers and diseases. Using simulation models to predict clinical study outcomes in prospective and retrospective trials.​
  • Defensins as regulators of chemokine and cytokine production. Peptides in saliva (e.g., defensins, histatins, etc.) have the ability to serve as downstream suppressors of cytokine signaling to recombinant hemagglutinin B (HagB) from the periodontal pathogen Porphyromonas gingivalis.​
  • Lipids as antimicrobial agents. Long-chain bases are present in the oral cavity have potent antimicrobial activity against oral pathogens, a finding important to pursuing their future potential in treating periodontal and oral infections.
  • Clinical studies support. Provides support for clinicians by performing chemokine and cytokine analysis on clinical samples.
Publications: 

Select Publications 2017-2019

  1. Bates, A. M., Garaicoa, J. L., Fischer, C. L., and Brogden, K. A. Diminished antimicrobial peptide and antifungal antibiotic activities against Candida albicans in denture adhesive. Antibiotics (Basel) 6(1), 2017.​ DOI: 10.3390/antibiotics6010006.
  1. Li, K., Wohlford-Lenane, C. L., Channappanavar, R., Park, J. E., Earnest, J. T., Bair, T. B., Bates, A. M., Brogden, K. A., Flaherty, H. A., Gallagher, T., Meyerholz, D. K., Perlman, S., McCray, P. B., Jr. Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci USA. 114(15):E3119-E3128, 2017.​ DOI: 10.1073/pnas.1619109114.
  1. Bates, A. M., Lanzel, E., Qian, F., Abbasi, T., Vali, S., and Brogden, K. A. Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC - a computational study. Oral Surg Oral Med Oral Pathol Oral Radiol. 124(2):157-164, 2017.​ DOI: 10.1016/j.oooo.2017.05.474.
  1. Raina, M., Bates, A. N., Fischer, C. L., Progulske-Fox, A., Abbasi, T., Vali, S., and Brogden, K. A. HBD3 regulates matrix metalloproteinase production in human NHDCs exposed to Porphyromonas gingivalis hemagglutinin B (HagB). J Periodontol. 89:361-369, 2018. DOI: 10.1002/JPER.17-0366.
  1. Brogden, K. A., Parashar, D., Hallier, A. R., Braun, T., Qian, F., Rizvi, N. A. Bossler, A. D., Milhem, M., Chan, T. A., Abbasi, T., and Vali, S. Computational simulation modeling of NSCLC patients: Clinical prediction and correlation of drug responder status to anti-PD-1 immunotherapy. BMC Cancer 18(1):225, 2018.​ DOI: 10.1186/s12885-018-4134-y
  1. Brogden, K. A., Parashar, D., Hallier, A. R., Braun, T., Qian, F., Rizvi, N. A. Bossler, A. D., Milhem, M., Chan, T. A., Abbasi, T., and Vali, S. Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy. BMC Cancer 18(1):413, 2018.​ DOI: 10.1186/s12885-018-4200-5.
  1. Bates, A. M., Gomez Hernandez, M. P., Lanzel, E. A., Qian, F., and Brogden, K. A. MMP and immunosuppressive biomarker profiles of seven HNSCC cell lines. Transl Cancer Res. 7(3):533-542, 2018. DOI: 10.21037/tcr.2018.05.09
  1. Bates, A. M., Fischer, C. L., Abhyankar, V. P., Johnson, G. K., Guthmiller, J. M., Progulske-Fox, A., and Brogden, K. A. Matrix metalloproteinase response of dendritic cell, gingival keratinocyte, and T-cell 3D co-cultures treated with Porphyromonas gingivalis hemagglutinin B. Int J Mol Sci. 19(12), 2018.​ DOI: 10.3390/ijms19123923.
  1. Pantzlaff, E., Busch, T., Dawson, D., Fischer, C. L., Avila Ortiz, G., Elangovan, S., Stanford, C. M., Brogden, K. A., and Butali, A. Systemic inflammation, obesity, and single nucleotide polymorphisms impact on gingival inflammation: a clinical pilot study. Michigan Journal of Medicine 3(1):40-53. 2018.​ DOI: 10.3998/mjm.13761231.0003.108.
  1. Abhyankar, V. P., Bates, A. M., Fischer, C. L., Johnson, G. K., Guthmiller, J. M., Progulske-Fox, A., and Brogden, K. A. Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B Data-in-Brief 22:964-970, 2018.​ DOI: 10.1016/j.dib.2018.12.087.
  1. Morio, K., Thayer, E. L., Bates, A. M., and Brogden, K. A.  255 nm LED kills Enterococcus faecalis and induces the production of cellular biomarkers in HEPM cells and gingival fibroblasts. J. Endod. 45(6):774-783, 2019.​ DOI: 10.1016/j.joen.2019.02.016.
  1. Fischer, C. L., Bates, A. M., Lanzel, E., Guthmiller, J. M., Johnson, G. K., Singh, N. K., Kumar, A., Vidva, R., Abbasi, T., Vali, S., Xie, X. J., Zeng, E., and Brogden, K. A. Multiscale computational models predict cell-cell biomarker profiles in inflammation and cancer. Sci Report. In review.
PubMed Publications: 

Click here to perform an automatic PubMed search of Dr. Brogden's publications.

National or International Professional Appointments and Activities: 

Dr. Brogden is a member of the American Society for Microbiology, a Fellow in the American Academy of Microbiology, and a member of Phi Zeta and the American Association for the Advancement of Science. He is on the Board of Scientific Reviewers for the Annals of Agricultural and Environmental Medicine (1992-present), Infection and Immunity (1998-2000), and Scientific Reports (present). He has co-edited multiple books including Virulence Mechanisms of Bacterial Pathogens, second and third editions (ASM Press, Washington, D.C.,1995 and 2000) and Polymicrobial Diseases (ASM Press, Washington, D.C., 2002).