Kim A. Brogden

Dr. Brogden joined the College of Dentistry in 2004 and is now an emeritus professor in the Department of Periodontics.
2004-present | Professor, Department of Periodontics |
Nov 2012-Jan 2021 | Director, Iowa Institute for Oral Health Research |
Jul 2017-Jan 2018 | Interim DEO, Department of Periodontics |
Oct 2014-Jan 2015 | Interim Associate Dean for Research |
2003-2004 | Research Program Representative, USDA, ARS, NADC, Ames, IA |
1999-2004 | Research Leader (Department Head), Respiratory Diseases, USDA, ARS, NADC, Ames, IA |
1999-2004 | Collaborating Professor, Cellular and Molecular Pathology specialty of Veterinary Pathology, Iowa State University, Ames, IA |
2001-2001 | National Program Leader for Animal Health, National Program Staff, USD, ARS, Beltsville, MD |
1981-1999 | Microbiologist, USDA, ARS, NADC, Ames, IA |
Dr. Brogden's research interests focus on the following areas.
- Predictive computational simulation models. Working with collaborators to develop predictive computational simulation models of immune cells, cancer cells, and co-cultured cells to predict extracellular and cellular biomarker readouts (including immunosuppressive immune checkpoint biomarkers) in an automated high-throughput system - characteristics useful for predicting immunotherapy responses important to controlling a variety of cancers and diseases. Using simulation models to predict clinical study outcomes in prospective and retrospective trials.
- Defensins as regulators of chemokine and cytokine production. Peptides in saliva (e.g., defensins, histatins, etc.) have the ability to serve as downstream suppressors of cytokine signaling to recombinant hemagglutinin B (HagB) from the periodontal pathogen Porphyromonas gingivalis.
- Lipids as antimicrobial agents. Long-chain bases are present in the oral cavity have potent antimicrobial activity against oral pathogens, a finding important to pursuing their future potential in treating periodontal and oral infections.
- Clinical studies support. Provides support for clinicians by performing chemokine and cytokine analysis on clinical samples.
Select Publications 2017-2019
- Bates, A. M., Garaicoa, J. L., Fischer, C. L., and Brogden, K. A. Diminished antimicrobial peptide and antifungal antibiotic activities against Candida albicans in denture adhesive. Antibiotics (Basel) 6(1), 2017. DOI: 10.3390/antibiotics6010006.
- Li, K., Wohlford-Lenane, C. L., Channappanavar, R., Park, J. E., Earnest, J. T., Bair, T. B., Bates, A. M., Brogden, K. A., Flaherty, H. A., Gallagher, T., Meyerholz, D. K., Perlman, S., McCray, P. B., Jr. Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci USA. 114(15):E3119-E3128, 2017. DOI: 10.1073/pnas.1619109114.
- Bates, A. M., Lanzel, E., Qian, F., Abbasi, T., Vali, S., and Brogden, K. A. Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC - a computational study. Oral Surg Oral Med Oral Pathol Oral Radiol. 124(2):157-164, 2017. DOI: 10.1016/j.oooo.2017.05.474.
- Raina, M., Bates, A. N., Fischer, C. L., Progulske-Fox, A., Abbasi, T., Vali, S., and Brogden, K. A. HBD3 regulates matrix metalloproteinase production in human NHDCs exposed to Porphyromonas gingivalis hemagglutinin B (HagB). J Periodontol. 89:361-369, 2018. DOI: 10.1002/JPER.17-0366.
- Brogden, K. A., Parashar, D., Hallier, A. R., Braun, T., Qian, F., Rizvi, N. A. Bossler, A. D., Milhem, M., Chan, T. A., Abbasi, T., and Vali, S. Computational simulation modeling of NSCLC patients: Clinical prediction and correlation of drug responder status to anti-PD-1 immunotherapy. BMC Cancer 18(1):225, 2018. DOI: 10.1186/s12885-018-4134-y
- Brogden, K. A., Parashar, D., Hallier, A. R., Braun, T., Qian, F., Rizvi, N. A. Bossler, A. D., Milhem, M., Chan, T. A., Abbasi, T., and Vali, S. Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy. BMC Cancer 18(1):413, 2018. DOI: 10.1186/s12885-018-4200-5.
- Bates, A. M., Gomez Hernandez, M. P., Lanzel, E. A., Qian, F., and Brogden, K. A. MMP and immunosuppressive biomarker profiles of seven HNSCC cell lines. Transl Cancer Res. 7(3):533-542, 2018. DOI: 10.21037/tcr.2018.05.09
- Bates, A. M., Fischer, C. L., Abhyankar, V. P., Johnson, G. K., Guthmiller, J. M., Progulske-Fox, A., and Brogden, K. A. Matrix metalloproteinase response of dendritic cell, gingival keratinocyte, and T-cell 3D co-cultures treated with Porphyromonas gingivalis hemagglutinin B. Int J Mol Sci. 19(12), 2018. DOI: 10.3390/ijms19123923.
- Pantzlaff, E., Busch, T., Dawson, D., Fischer, C. L., Avila Ortiz, G., Elangovan, S., Stanford, C. M., Brogden, K. A., and Butali, A. Systemic inflammation, obesity, and single nucleotide polymorphisms impact on gingival inflammation: a clinical pilot study. Michigan Journal of Medicine 3(1):40-53. 2018. DOI: 10.3998/mjm.13761231.0003.108.
- Abhyankar, V. P., Bates, A. M., Fischer, C. L., Johnson, G. K., Guthmiller, J. M., Progulske-Fox, A., and Brogden, K. A. Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B Data-in-Brief 22:964-970, 2018. DOI: 10.1016/j.dib.2018.12.087.
- Morio, K., Thayer, E. L., Bates, A. M., and Brogden, K. A. 255 nm LED kills Enterococcus faecalis and induces the production of cellular biomarkers in HEPM cells and gingival fibroblasts. J. Endod. 45(6):774-783, 2019. DOI: 10.1016/j.joen.2019.02.016.
- Fischer, C. L., Bates, A. M., Lanzel, E., Guthmiller, J. M., Johnson, G. K., Singh, N. K., Kumar, A., Vidva, R., Abbasi, T., Vali, S., Xie, X. J., Zeng, E., and Brogden, K. A. Multiscale computational models predict cell-cell biomarker profiles in inflammation and cancer. Sci Report. In review.
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Dr. Brogden is a member of the American Society for Microbiology, a Fellow in the American Academy of Microbiology, and a member of Phi Zeta and the American Association for the Advancement of Science. He is on the Board of Scientific Reviewers for the Annals of Agricultural and Environmental Medicine (1992-present), Infection and Immunity (1998-2000), and Scientific Reports (present). He has co-edited multiple books including Virulence Mechanisms of Bacterial Pathogens, second and third editions (ASM Press, Washington, D.C.,1995 and 2000) and Polymicrobial Diseases (ASM Press, Washington, D.C., 2002).