Dr. Isabelle Denry received her DDS and her PhD from the University of Paris, France. After 20 years at the Ohio State University College of Dentistry, she moved to the University of Iowa, where she is a professor at the Iowa Institute for Oral Health Research and Department of Prosthodontics. Dr. Denry has written numerous articles on ceramics for dental applications and is a reviewer for many dental and engineering journals. Her research has been supported by Federal funds for nearly twenty years and she has been granted three US patents. Her latest work has extended to the field of biomedical engineering and development of resorbable ceramics for bone replacement.
Our research focus is on ceramics for biomedical and dental applications. We are developing bioactive ceramic scaffolds with engineered topography and chemistry for bone replacement. By modifying the chemistry of the base glass-ceramic, we are able to adjust the resorbability of the scaffolds. Upcoming aims include testing of these scaffolds in a rat calvarial defect model and monitoring bone formation using in vivo micro-CT. A wide variety of surface microstructures can also be produced to emulate cell-friendly scaffold topographies. Other areas of interest are the failure analysis of dental ceramics and the development of novel high toughness ceramics for CAD-CAM applications.
(1: Anadioti E, Aquilino SA, Gratton DG, Holloway JA, Denry IL, Thomas GW, Qian F. Internal fit of pressed and computer-aided design/computer-aided manufacturing ceramic crowns made from digital and conventional impressions. J Prosthet Dent. 2015 Apr;113(4):304-9. doi: 10.1016/j.prosdent.2014.09.015. Epub 2014 Dec 6. PubMed PMID: 25488521.
2: Denry I, Kelly JR. Emerging ceramic-based materials for dentistry. J Dent Res. 2014 Dec;93(12):1235-42. doi: 10.1177/0022034514553627. Epub 2014 Oct 1. Review. PubMed PMID: 25274751.
3: Anadioti E, Aquilino SA, Gratton DG, Holloway JA, Denry I, Thomas GW, Qian F. 3D and 2D marginal fit of pressed and CAD/CAM lithium disilicate crowns made from digital and conventional impressions. J Prosthodont. 2014 Dec;23(8):610-7. doi: 10.1111/jopr.12180. Epub 2014 Jul 3. PubMed PMID: 24995593.
4: Denry I, Holloway JA. Low temperature sintering of fluorapatite glass-ceramics. Dent Mater. 2014 Feb;30(2):112-21. doi: 10.1016/j.dental.2013.10.009. Epub 2013 Nov 16. PubMed PMID: 24252652; PubMed Central PMCID: PMC3899825.
5: Denry I. How and when does fabrication damage adversely affect the clinical performance of ceramic restorations? Dent Mater. 2013 Jan;29(1):85-96. doi: 10.1016/j.dental.2012.07.001. Epub 2012 Jul 21. Review. PubMed PMID: 22819392.
6: Denry I, Holloway JA, Gupta PK. Effect of crystallization heat treatment on the microstructure of niobium-doped fluorapatite glass-ceramics. J Biomed Mater Res B Appl Biomater. 2012 Jul;100(5):1198-205. doi: 10.1002/jbm.b.32684. Epub 2012 Mar 27. PubMed PMID: 22454333; PubMed Central PMCID: PMC3512195.
7: Kushwaha M, Pan X, Holloway JA, Denry IL. Differentiation of human mesenchymal stem cells on niobium-doped fluorapatite glass-ceramics. Dent Mater. 2012 Mar;28(3):252-60. doi: 10.1016/j.dental.2011.10.010. Epub 2011 Nov 9. Erratum in: Dent Mater. 2012 Jul;28(7):810. PubMed PMID: 22078764; PubMed Central PMCID: PMC3279629.
8: Denry IL, Peacock JJ, Holloway JA. Effect of heat treatment after accelerated aging on phase transformation in 3Y-TZP. J Biomed Mater Res B Appl Biomater. 2010 Apr;93(1):236-43. doi: 10.1002/jbm.b.31580. PubMed PMID: 20091919.
9: Shah K, Holloway JA, Denry IL. Effect of coloring with various metal oxides on the microstructure, color, and flexural strength of 3Y-TZP. J Biomed Mater Res B Appl Biomater. 2008 Nov;87(2):329-37. doi: 10.1002/jbm.b.31107. PubMed PMID: 18433010.
10: Denry I, Kelly JR. State of the art of zirconia for dental applications. Dent Mater. 2008 Mar;24(3):299-307. Epub 2007 Jul 19. Review. PubMed PMID: 17659331.
11: Kelly JR, Denry I. Stabilized zirconia as a structural ceramic: an overview. Dent Mater. 2008 Mar;24(3):289-98. Epub 2007 Jul 12. Review. PubMed PMID: 17624420.
12: Denry IL, Holloway JA. Effect of crystallization heat treatment on the microstructure and biaxial strength of fluorrichterite glass-ceramics. J Biomed Mater Res B Appl Biomater. 2007 Feb;80(2):454-9. PubMed PMID: 16838349.
13: Denry IL, Holloway JA. Microstructural and crystallographic surface changes after grinding zirconia-based dental ceramics. J Biomed Mater Res B Appl Biomater. 2006 Feb;76(2):440-8. PubMed PMID: 16184529.
14: Denry IL, Holloway JA, Nakkula RJ, Walters JD. Effect of niobium content on the microstructure and thermal properties of fluorapatite glass-ceramics. J Biomed Mater Res B Appl Biomater. 2005 Oct;75(1):18-24. PubMed PMID: 16025471.
15: Denry IL, Holloway JA. Elastic constants, Vickers hardness, and fracture toughness of fluorrichterite-based glass-ceramics. Dent Mater. 2004 Mar;20(3):213-9. PubMed PMID: 15209226.
16: Denry IL, Holloway JA. Effect of heat pressing on the mechanical properties of a mica-based glass-ceramic. J Biomed Mater Res B Appl Biomater. 2004 Jul 15;70(1):37-42. PubMed PMID: 15199581.
17: Denry IL, Holloway JA. Effect of post-processing heat treatment on the fracture strength of a heat-pressed dental ceramic. J Biomed Mater Res B Appl Biomater. 2004 Feb 15;68(2):174-9. PubMed PMID: 14737765.
18: Denry IL, Baranta G, Holloway JA, Gupta PK. Effect of processing variables on texture development in a mica-based glass-ceramic. J Biomed Mater Res B Appl Biomater. 2003 Feb 15;64(2):70-7. PubMed PMID: 12516081.
19: Denry IL, Holloway JA. Effect of additives on the microstructure and thermal properties of a mica-based glass-ceramic. J Biomed Mater Res. 2002;63(2):146-51. PubMed PMID: 11870647.
20: Denry IL, Holloway JA. Effect of sodium content on the crystallization behavior of fluoramphibole glass-ceramics. J Biomed Mater Res. 2002;63(1):48-52. PubMed PMID: 11787028.
21: Scherrer SS, Denry IL, Wiskott HW, Belser UC. Effect of water exposure on the fracture toughness and flexure strength of a dental glass. Dent Mater. 2001 Jul;17(4):367-71. PubMed PMID: 11356215.
22: Denry IL, Holloway JA, Colijn HO. Phase transformations in a leucite-reinforced pressable dental ceramic. J Biomed Mater Res. 2001 Mar 5;54(3):351-9. PubMed PMID: 11189040.
23: Denry IL, Holloway JA. Effect of magnesium content on the microstructure and crystalline phases of fluoramphibole glass-ceramics. J Biomed Mater Res. 2000;53(4):289-96. PubMed PMID: 10898869.
24: Denry IL, Holloway JA, Tarr LA. Effect of heat treatment on microcrack healing behavior of a machinable dental ceramic. J Biomed Mater Res. 1999;48(6):791-6. PubMed PMID: 10556842.
25: Scherrer SS, Denry IL, Wiskott HW. Comparison of three fracture toughness testing techniques using a dental glass and a dental ceramic. Dent Mater. 1998 Jul;14(4):246-55. PubMed PMID: 10379252.
26: Denry IL, Holloway JA, Rosenstiel SF. Crystallization kinetics of a low-expansion feldspar glass for dental applications. J Biomed Mater Res. 1998 Sep 5;41(3):398-404. PubMed PMID: 9659609.
27: Denry IL, Holloway JA, Rosenstiel SF. Effect of ion exchange on the microstructure, strength, and thermal expansion behavior of a leucite-reinforced porcelain. J Dent Res. 1998 Apr;77(4):583-8. PubMed PMID: 9539461.
28: Holloway JA, Denry IL, Rosenstiel SF. Surface layer characterization after dual ion exchange of a leucite-reinforced dental porcelain. Int J Prosthodont. 1997 Mar-Apr;10(2):136-41. PubMed PMID: 9206453.
29: Denry IL, Mackert JR Jr, Holloway JA, Rosenstiel SF. Effect of cubic leucite stabilization on the flexural strength of feldspathic dental porcelain. J Dent Res. 1996 Dec;75(12):1928-35. PubMed PMID: 9033446.
30: Seghi RR, Denry IL, Rosenstiel SF. Relative fracture toughness and hardness of new dental ceramics. J Prosthet Dent. 1995 Aug;74(2):145-50. PubMed PMID: 8537920.
31: Denry IL, Rosenstiel SF, Holloway JA, Niemiec MS. Enhanced chemical strengthening of feldspathic dental porcelain. J Dent Res. 1993 Oct;72(10):1429-33. PubMed PMID: 8408886.
32: Denry IL, Rosenstiel SF. Flexural strength and fracture toughness of Dicor glass-ceramic after embedment modification. J Dent Res. 1993 Mar;72(3):572-6. PubMed PMID: 8450116.
33: Rosenstiel SF, Denry IL, Zhu W, Gupta PK, Van der Sluys RA. Fluoroalkylethyl silane coating as a moisture barrier for dental ceramics. J Biomed Mater Res. 1993 Mar;27(3):415-7. PubMed PMID: 8360210.
34: Seghi RR, Denry I, Brajevic F. Effects of ion exchange on hardness and fracture toughness of dental ceramics. Int J Prosthodont. 1992 Jul-Aug;5(4):309-14. PubMed PMID: 1520452.
35: Seghi RR, Denry I. Effects of external bleaching on indentation and abrasion characteristics of human enamel in vitro. J Dent Res. 1992 Jun;71(6):1340-4. PubMed PMID: 1613185.
36: Denry I, Guymont M, Portier R. . J Biomater Dent. 1986 Jul;2(3):197-204. French. PubMed PMID: 3465729.
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Dr. Denry is a member of both the American and International Associations for Dental Research, the American Ceramic Society, the Society for Biomaterials and the Academy of Dental Materials. She is also a member of the Omicron Kappa Upsilon Honor Dental Society.