Research Activities: Dr. Schneider is an NIH-funded investigator and his research focuses on bone cell biology as it relates to implant osseointegration and bone tissue engineering. His research interests focus on several questions:
1. How does osteoblast cell adhesion regulate bone growth at the molecular level?
2. Does implant surface microtopography influence osteoblast differentiation?
3. Can bone tissue be engineered using injectable scaffolds?
4. Can microgravity environments be used for osseous tissue engineering?
Clinical Activities: Dr. Schneider is a board eligible prosthodontist and is actively involved in patient treatment within the Department of Prosthodontics' intramural practice. He treats patients in need of removable, fixed, or implant-supported prostheses.
National or International Professional Appointments or Activities: Dr. Schneider is a member of the American College of Prosthodontics, the American and International Associations for Dental Research, and the American Dental Association. He currently serves as a basic science research editor for Journal of Prosthodontics. He is an ad hoc reviewer of articles for Journal of Dental Research; Prosthodontics; Oral and Maxillofacial Implants; Clinical Orthopedics; Biomaterials; and Clinical Cancer Research. He has served, or is serving, on committees for the International and American Associations for Dental Research, the American College of Prosthodontists, the International Congress of Oral Implantologists, and the National Institutes of Health.
Recent Publications:
Ko J. Zaharias R. Seabold D. Laffoon J. Schneider G. Osteoblast differentiation is enhanced in rotary cell culture simulated microgravity environments. Journal of Prosthodontics (In Press).
Isa Z. Schneider G. Zaharias R. Seabold D. Stanford C. Effects of fluoride modified titanium surfaces on osteoblast proliferation and gene expression. International Journal of Oral and Maxillofacial Implants 21:203-211, 2006.Oldak J. Wen H. Schneider G. Stanford C. Tissue engineering strategies for future generations of osseous dental implants. Periodontologyy 2000 41:1-19, 2006.
Baman N. Schneider G. Terry T. Zaharias R. Salem, A. Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. International Journal of Nanomedicine 1(2):1-5, 2006.
Stanford C. Schneider G. Masaki C. Zaharias R. Seabold D. Eckdahl J. Di Paola J. Effect of fluoride modified titanium dioxide grit blasted implant surfaces on platelet activation and osteoblast differentiation. Applied Osseointegration Research 5:24-30, 2006. Masaki C. Schneider G. Zaharias R. Seabold D. Stanford C. "Effects of implant surface microtopographies on osteoblast gene expression." Clinical Oral Implants Research 16:650-656, 2005.Hess A. Postovit L. Margaryan N. Seftor E. Schneider G. Schaller, M. Seftor R. Nickoloff B. Hendrix M. Focal adhesion kinase promotes the aggressive melanoma phenotype. Cancer Research 65(21):9851-9860, 2005.
Du C. Schneider G. Zaharias R. Abbott C. Seabold D. Stanford C. Oldak J. Apatite/Amelogenin coating on titanium promotes osteogenic gene expression. Journal of Dental Research 84(11):1070-1074, 2005. Kremenak N. Bayne S. McCracken M. Schneider G. Writing the basic science research report. Journal of Prosthodontics 14(2):150-151, 2005. Sood A. Coffin J. Schneider G. Fletcher M. DeYoung B. Gruman L. Gershenson D, Schaller M, Hendrix M. "Biological significance of FAK in ovarian cancer: role in migration and invasion." American Journal of Pathology 126(2):173-178, 2004.Lee A. Schneider G. Southard T. "Root resorption: the possible role of extracellular matrix proteins." American Journal of Orthodontics and Dentofacial Orthopedics 1165(4):1087-1095, 2004.
Keller J. Bergstrom M. Roehm M. Schneider G. "Osteoporotic like bone conditions affect osseointegration of implants. International Journal of Oral Maxillofacial Implants 19:687-694, 2004.
Gasparoni A. Fonzi L. Johnson G. Wertz P. Schneider G. Squier C. "Comparison of differentiation markers in normal and squamous cell carcinoma cell cultures." Archives of Oral Biology 49(8):653-664, 2004.
Schneider G. Zaharias R. Seabold D. Stanford C. Keller J. "Differentiation of preosteoblasts is affected by implant surface microtopographies." Journal of Biomedical Materials Research 69A(3):462-468, 2004.
Cho P. Schneider G. Krizan K. Keller JC. "Examination of the bone implant interface in experimentally induced osteoporotic bone." Implant Dentistry 13:79-87, 2004.
Casa M. Johnson G. Schneider G. Gasparoni A. Squier C. Fonzi L. "Cell membrane molecules in oral cancer." Dental Cadmos 72:55-65, 2004.
Schneider G.. English AE. Abraham M. Zaharias R. Stanford C. Keller J. "The effect of hydrogel charge density on cell attachment." Biomaterials 25(15):3028-3028, 2004.
Peripanayagam H. Schneider G. Holtman K. Zaharias R. Stanford C. "Altered Cbfa1 expression and biomineralization in an osteosarcoma cell line." Journal of Orthopaedic Research 22:404-410, 2004.
Stanford C. Schneider G. "Functional behavior of bone around dental implants." Gerodontology 21(2):71-7, 2004.
Fakhry A. Schneider G. Zaharias R. Senel S. "Chitosan supports the initial attachment and spreading of osteoblasts preferentially over fibroblasts." Biomaterials 25(11):2075-2079, 2004.
Keller J. Schneider G. Stanford C. Kellogg B. "Effects of dental implant microtopography on osteoblast cell attachment." Implant Dentistry 12(2):175-181, 2003.
Schneider GB. Perinpanayagam H. Clegg M. Zaharias R. Keller J. Stanford C. "Implant surface roughness affects osteoblast gene expression." Journal of Dental Research 82(5):372-376, 2003.
Schneider GB. Zaharias R. Gardner L. Kurago Z. Schaller M. Hendrix M. "Elevated focal adhesion kinase expression facilitates oral tumor cell invasion." Cancer 95(12):2508-2515, 2002.
Gasparoni A. Chavez A. Fonzi L. Johnson GK. Schneider GB. Squier CA. "Subcellular localization of beta-catenin malignant cell lines and squamous cell carcinomas of the oral cavity." Journal of Oral Pathology and Medicine 31(7):385-394, 2002.
Odero V. Ellis Z. Schneider GB. Seftor E. Seftor R. Koland J. Hendrix MJC. "Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells." Biochemical and Biophysical Research Communications 295:800-805, 2002.
Schneider GB. "Collaborations must be developed." Journal of Prosthodontics 11:2-3, 2002.
Davies KR. Schneider GB. Southard TE. Hillis SL. Wertz PW. Finkelstein M. "Deciduous canine and permanent lateral incisor differential root resorption." American Journal of Orthodontics and Dentofacial Orthopedics 120:339-347, 2001.
Peripanayagam H. Zaharias R. Stanford C. Brand R. Keller J. Schneider GB. "Early cell adhesion events differ between osteoporotic and non-osteoporotic osteoblasts." Journal of Osteopaedic Research 19(6):993-1000, 2001.
Schneider GB. Zaharias R. Stanford C. "Osteoblast integrin adhesion and signaling regulates mineralization." Journal of Dental Research 80(6):1540-1544, 2001.
Hess AR. Seftor EA. Gardner LMG. Charles-Kinch K. Schneider GB. Seftor REB. Kinch MS. Hendrix MJC. "Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase (Eck/Eph2)." Cancer Research 61:3250-3255, 2001.
Schneider GB. Whitson SW. Cooper L. "Restricted and coordinated expression of beta3 integrin and bone sialoprotein during cultured osteoblast differentiation." Bone 24:321-327, 1999.
Schneider G. Simmons K. Nason R. Felton D. "Occlusal rehabilitation using implants for orthodontic anchorage." Journal of Prosthodontics 7:232-236, 1998.
Schneider G. Hamano H. Cooper L. "In vitro evaluation of hsp27 as an inhibitor of actin polymerization. Hsp27 limits focal adhesion formation after heat shock." Journal of Cell Physiology 177:575-584, 1998.
Shen Y. Schneider G. Cloutier JF. Veillette A. Schaller M. "Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin." Journal of Biological Chemistry 273:6474-6481, 1998.
Schneider GB. Gilmore AP. Lohse DL. Romer LH. Burridge KB. "Microinjection of protein tyrosine phosphatases into fibroblasts disrupts focal adhesions and stress fibers." Cell Adhesion and Communication 5:207-219, 1998.
Uoshima M. Yan YZ. Schneider G. Aukhil I. "The alternatively spliced domains EIIIB and EIIIA of human fibronectin affect cell adhesion and spreading." Journal of Cell Science 110:2271-2280, 1997.
Pavalko FM. Schneider G. Burridge K. Lim SS. "Immunodetection of alpha-actinin in focal adhesions is limited by antibody inaccessibility." Experimental Cell Research 217:534-540, 1995.
Schneider G. Burridge K. "Formation of focal adhesions by osteoblasts adhering to different substrata." Experimental Cell Research 214:264-269, 1994.