Teaching Activities:
Clinical Activities:
Research Activities: Antimicrobial peptides are integral components of innate defense against microbial infection and disease. Defensins, among the better studied antimicrobial peptides, induce and direct the adaptive immune response. Dr. Brogden's area of research focuses on the basic parameters of defensin-induced adaptive immunity in the oronasal cavity. This includes identifying the defensins involved, assessing the defensin-induced response to Porphyromonas gingivalis HagB, fimbriae, and capsular polysaccharide, and elucidating the basic mechanism through defensin-stimulated dendritic cells. These studies may identify ways to augment and direct and adaptive immune response that would likely hinder the pathogensis of periodontal disease (e.g., class switching of antibodies to high avidity isotypes, etc.) and possibly lead to the realization of an elaborate innate immune signaling system that processes bacterial antigens differently.
National or International Professional Appointments or Activities: Dr. Brogden is a member of the American Society for Microbiology, a Fellow in the American Academy of Microbiology, and a member of Phi Zeta and the American Association for the Advancement of Science. He is on the Board of Scientific Reviewers for the Annals of Agricultural and Environmental Medicine (1992 to present) and was on the Board for Infection and Immunity (1998-2000). He has co-edited three books: Virulence Mechanisms of Bacterial Pathogens, 2nd and 3rd editions (ASM Press, Washington, D.C., 1995 and 2000) and Polymicrobial Diseases (ASM Press, Washington, D.C., 2002).
Key Select Publications:
Brogden, K. A., De Lucca, A. J. Bland, J., and Elliott, S. Isolation of an ovine pulmonary surfactant-associated anionic peptide bactericidal for Pasteurella haemolytica. Proceedings of the National Academy of Sciences of the U.S.A. 93:412-416, 1996.
Brogden, K. A., Heidari, M., Sacco R. E., Palmquist, D., Guthmiller, J. M., Johnson, G. K., Jia, H. P., Tack, B. F., and McCray, P. B. Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiology and Immunology 18:95-99, 2003.
Brogden, K. A., Ackermann, M., McCray, P. B. and Tack, B. F. Antimicrobial peptides in animals and their role in host defences. International Journal of Antimicrobial Agents 22:465-478, 2003.
Brogden, K. A., Ackermann, M., Zabner J., and Welsh, M. J. Antimicrobial peptides suppress microbial infections and sepsis in animal models. In: Mammalian Antimicrobial Peptides, Advances in Molecular and Cellular Microbiology Series. Devine, D. D. and Hancock, R. E. W. (eds). Cambridge University Press, pp. 189-228, 2004.
Brogden, K. A., Guthmiller, J. M. and Taylor, C. E. Human polymicrobial infections. Lancet 365:253-255, 2005.
Brogden, K. A. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nature Reviews Microbiology 3:1-13, 2005.
Brogden, K. A. Guthmiller JM. Salzet M. and Zasloff M. The nervous system and innate immunity: the neuropeptide connection. Nature Immunology 6:558-564, 2005.
Kim A. Brogden
University of Iowa College of Dentistry
Department of Periodontics and Dows Institute for Dental Research
Dental Science Building - N401
Iowa City, Iowa 52242
319-335-6813