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Brief Professional Resume:

Dr. Brogden joined the College of Dentistry in 2004. He is a professor in the Dows Institute for Dental Research and the Department of Periodontics.

Research Activities

: Dr. Brogden's research focuses on the basic parameters of defensin-induced adaptive immunity in the oronasal cavity. This includes identifying the defensins involved, assessing the defensin- induced response to Porphyromonas gingivalis HagB, fimbriae, and capsular polysaccharide, and elucidating the basic mechanism through defensin-stimulated dendritic cells. These studies may identify ways to augment and direct an adaptive immune response that would likely hinder the pethogenesis of periodontal disease (e.g., class switching of antibodies to high avidity isotypes, etc.) and possibly lead to the realization of an elaborate innate immune signaling system that processes bacterial antigens differently.

National or International Professional Appointments and Activities

: Dr. Brogden is a member of the American Society for Microbiology, a Fellow in the American Academy of Microbiology, and a member of Phi Zeta and the American Association for the Advancement of Science. He is on the Board of Scientific Reviewers for the Annals of Agricultural and Environmental Medicine (1992-present) and was on the Board for Infection and Immunity (1998-2000). He has co-edited three books: Virulence Mechanisms of Bacterial Pathogens, second and third editions (ASM Press, Washington, D.C. (1995 and 2000) and Polymicrobial Diseases (ASM Press, Washington, D.C., 2002).

Key Select Publications:

• Brogden, K. A., Ackermann, M., Zabner J., and Welsh, M. J. Antimicrobial peptides suppress microbial infections and sepsis in animal models. In: Mammalian Antimicrobial Peptides, Advances in Molecular and Cellular Microbiology Series. Devine, D. D. and Hancock, R. E. W. (eds). Cambridge University Press, pp. 189-228, 2004.
• Brogden, K. A., Guthmiller, J. M. and Taylor, C. E. Human polymicrobial infections. Lancet 365:253-255, 2005.
• Brogden, K. A. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nature Reviews Microbiology 3:1-13, 2005.
• Brogden, K. A. Guthmiller JM. Salzet M. and Zasloff M. The nervous system and innate immunity: the neuropeptide connection. Nature Immunology 6:558-564, 2005.