Dr. Azeez Butali, Dental Research and Department of Oral Pathology, Radiology and Medicine, has received a three-year, $597,645 Roy C. Carver Charitable Trust grant to develop a biorepository for research into oral health and disease. The award will support the collection of 12,500 biological samples that include saliva, teeth, oral tissues, and dental and medical information from 10,000 individuals. The purpose of the biorepository is threefold:
1. To establish a biorepository that will combine biological materials, dental and medical records;
2. To establish a fully integrated medical, genetic and dental patient record to improve quality of care provided to the patients, as well as enhance broader quality research across the University of Iowa medical and dental facilities;
3. To make these data and biological materials available to researchers at the University of Iowa and collaborators in order to conduct ground-breaking research, to deliver personalized precision medicine and improve patients' health.
Dr. Butali is principal investigator. Drs. Arwa Owais, Department of Pediatric Dentistry, and Veersathpurush Allareddy, Department of Orthodontics are co-principal investigators.
Dr. Isabelle Denry, Dental Research and Department of Prosthodontics, has received a two-year, $418,907 NIH grant for her research project, "Synergistic Phase Combination for High Strength Ultrafine-Grained Bioceramics." Dr. Julie Holloway, chair of the Department of Prosthodontics, is a co-investigator.
With the aging population and longer life expectancy, the total number of hip and knee arthroplasty revision procedures is expected to exceed 67,000 and 120,000 per year by 2020, with an estimated health care cost of $2.2 billion per year. Ceramic surfaces are attractive for both orthopedic and dental applications because of low wear rates but they are brittle and susceptible to catastrophic failure.
Drs. Denry and Holloway propose to develop a novel zirconia/nanospinel bioceramic realizing a synergistic phase combination for high reliability and strength and low abrasiveness, while longer life performance will reduce costs associated with revision surgeries and replacement of single or large-span dental restorations.
Brad A. Amendt, associate dean for research at the College of Dentistry, has been named Dentistry Centennial Professor of Research. He was conferred the five-year appointment during the 63rd Annual Meeting of the Iowa Section of the American Association for Dental Research (AADR), which was held February 16.
Dr. Amendt's research focuses on understanding the role of transcription factors and signaling pathways in tooth and craniofacial development. His lab studies the expression and regulation of transcription factor genes and signaling processes involved in craniofacial/tooth development; the molecular basis of selected human genetic disorders; and the role of stem cells and microRNAs in regulating craniofacial and regenerative medicine.
Dr. Amendt is know internationally as one of the world's leading authorities on micro-RNA research and cell plasticity.
Dr. Clark Stanford, former associate dean for research, was the first to be named Dentistry Centennial Professor of Clinical Research. He held the professorship from 2001-2014 before accepting the deanship of the University of Illinois, Chicago (UIC) College of Dentistry.
Dr. Azeez Butali, Iowa Institute for Oral Health Research, and Department of Oral Pathology, Radiology, and Medicine, has received a one-year, $249,000 National Institutes of Health (NIH) grant for his research, "Genetic Studies of Nonsyndromic Clefts in Populations of African Descent." The focus of his study is to understand the complex genetic etiology of orofacial clefts (OFC) by determining the genetic variations that contribute to OFC in homogenous African populations and relate these findings to prevention and clinical management of the disease. Specifically, this study will focus on genome-wide association studies (common variant association studies and rare variant association studies (RVAS) of non-syndromic clefts using homogenous samples from Africa). Dr. Butali is the principal investigator.
In addition to this award, he also received an X01 NIH grant. Through the X01 award, the Center for Inherited Disease Research (CIDR) at Johns Hopkins University, Baltimore, MD, genotyped 2.2. million single nucleotide polymorphisms (SNPs) on approximately 3,500 samples from Africa. The cost of this genotyping was paid by NIH directly to the CIDR.