Local AADR Research Day
February 11, 2014
To see the abstracts that were presented
last year at the 2013 Annual Meeting of the
Iowa Section of the American Association
for Dental Research, click on the program.
Students, faculty and staff are invited to activities, and to attend the evening reception and awards banquet. NOTE: D1-D3 classes and clinics will be closed this year. D4 students who are participating in Research Day, please sign up with Dean Catherine Solow's office as soon as possible. Dr. Solow's office will then notify course/clinic instructors.
Iowa Section of the American Association for Dental Research
(AADR) 60th Annual Meeting, Tuesday February 19th, 2013
|7:30 a.m.||Reception with Coffee and Rolls (1st floor link)|
Welcome Address(Galagan Auditoria)
Dr. David Johnsen
Dr. Clark Stanford
Keynote Speaker Introduction
Keynote Address (Galagan Auditoria)
Dr. Mark W. Lingen
|9:30 a.m. - 11:30 a.m.||Oral Presentations (Galagan Auditoria A-C, Oral B Classroom N212)|
|11:30 a.m. - 12:40 p.m.||Poster & Table Clinic Presentations (Dows Institute for Dental Research, & 1st, 3rd, 4th floor links)|
Awards Banquet Reception with Cash Bar
(Holiday Inn & Conference Center)
Awards Banquet Dinner & Awards
(Holiday Inn & Conference Center)
Our Keynote Speaker
Mark W. Lingen, DDS, PhD, FRCPath, is a professor in the Departments of Pathology, Medicine, and Radiation & Cellular Oncology at the University of Chicago, Pritzker School of Medicine.
Targeting the Angiogenic Phenotype for the Treatment and Prevention of Oral Cancer
Dr. Mark W. Lingen is a Professor in the Departments of Pathology, Medicine, and Radiation & Cellular Oncology at the University of Chicago, Pritzker School of Medicine. Dr. Lingen comes from a “dental family” that includes a total of 5 graduates of Northwestern University Dental School dating back to 1894. In addition to dental school, he completed his residency in Oral & Maxillofacial Pathology as well as a PhD in Cellular and Molecular Pathology at Northwestern. Dr. Lingen is the Editor in Chief for the Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (TripleO) journal. His research dealing with the tumor angiogenesis and prevention of oral cancer is funded by the National Institutes of Health and has resulted in more than 100 papers, book chapters and abstracts. He is a Diplomate of the American Board of Oral & Maxillofacial Pathology as well as a Fellow of both the American and International College of Dentists as well as a Fellow of the Royal College of Pathologists.
His research group is investigating of number of basic and translational aspects of tumor angiogenesis using oral cancer as a model system. His lab cloned NOL7, a novel gene that induces an anti-angiogenic phenotype and suppresses in vivo tumor growth by 95%. NOL7 acts as a master regulator by modulating the expression of angiogenesis-associated mRNAs via both steady-state downregulation and posttranscriptional upregulation. NOL7 itself is positively regulated by the retinoblastoma (Rb) gene, supporting the paradigm shift in the field of cancer biology that Rb can act as a positive regulator of gene transcription. Their long-term goal is to understand how transcriptional and posttranscriptional regulation of angiogenesis-related mRNAs contributes to the expression of the phenotype and to leverage this knowledge to develop novel therapeutic approaches. They are also pursuing the hypothesis that inhibitors of angiogenesis are effective chemopreventive agents for preventing premalignant oral cavity lesions from progressing to oral cancer. The expression of the angiogenic phenotype is both an early and an essential step in the development of oral cancer, making it an attractive target for cancer prevention. The long-term goal of their work is to develop novel, nontoxic chemopreventive strategies for oral cancer that are based upon the inhibition of angiogenesis. Using a mouse model, they have demonstrated that ABT-510 (a global inhibitor of angiogenesis) and ZD6474 (a dual tyrosine kinase inhibitor (TKI) against EGFR and VEGFR-2) significantly decreased the incidence of dysplasia and oral cancer. As a result of these studies, they have initiated a Phase II, placebo controlled, randomized trial that is assessing the pharmacodynamic and clinical effects of ZD6474, in patients at high-risk for developing oral cancer. They are also investigating the mechanisms of acquired resistance in response prolonged chemopreventive therapy. Such modeling will enable them to test the hypothesis that acquired resistance to inhibitors of angiogenesis can be reversed, thereby prolonging chemopreventive activity. In addition, they are testing the feasibility of using biodegradable nanoparticles for the local delivery of anti-angiogenic agents for both cancer treatment and prevention, thereby decreasing systemic toxicities.
Deadline: January 7, 2014
Use your HawkID and password to enter your abstract.
Please see the description of the awards and select your choice of competition(s) when entering your abstract.
Description of the Awards
Ed Media Poster Material Submission Deadline: January 31, 2013
- Poster Production Guidelines:
TEXT: Text is preferred in Microsoft Word. PowerPoint is acceptable.
IMAGES: It is preferable to submit high-quality original images/illustrations that have not previously been embedded in PowerPoint or Word. If these original images are unavailable except in embedded form, we will accept them in PowerPoint or Word, but some quality compromises may be necessitated. Images taken from the web usually are not acceptable.
ABSTRACT: Abstract and abstract number (for poster) needs to be supplied by presenter when possible.
Work on your poster WILL NOT BEGIN until you have come in person with your materials on a thumb drive to Educational Media Services to review materials and layout issues with Kasey or Pat.
All AADR members, research staff, and students involved in dental research are invited to attend the awards banquet and buffet dinner that will be held at the Holiday Inn & Conference Center. Cocktails (cash bar) and conversation will begin at 5:00 PM and dinner will begin at 6:00 PM.
If you submitted an abstract and you are participating in any of the awards categories, we require your attendance at the banquet for the presentation of the awards.
Please fill out the Banquet PDF form and return a hard copy of this form with a check, payable to the Local AADR, to Sharon Seydel (N418) by Friday, February 8th, 2013.
For additional information, please contact Sherry Timmons ( 5-7408 ), or Sharon Seydel ( 5-7389 ).