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Biomaterials, Bone & Tissue Engineering

The replacement of tissues and organs with synthetic materials has become an increasingly important therapeutic modality and raises important questions about tissue response to a variety of substances. In dentistry, the clinical use of dental implants has intensified interest in collegiate faculty research, which examines changes in implant surfaces that may affect the attachment of soft tissue to implant surfaces, facilitate integration of a prosthesis with bone, or address the relationship between osteoporosis and oral health.  Technologies and applications that involve biomaterials and tissue engineering. Applications include: restorative material adhesion,  osseous tissue reconstruction, tooth replacement therapies

Primary researcher: Steve Armstrong
Dentin and enamel adhesion/durability; evaluation of direct restorative materials.
Primary researcher: Gustavo Avila-Ortiz
Alveolar bone, including understanding healing dynamics based on local and systemic individual patient features; analysis of site-specific factors that determine bone quality; evaluation of therapeutic strategies to prevent alveolar ridge resorption after tooth loss; implant site development techniques, in particular, sinus floor elevation.
Primary researcher: Isabelle Denry
Ceramics for biomedical applications: development and characterization; characterization of dental ceramics: crystalline phases, microstructure, structure/properties relationships; development of dental ceramics with tailored properties; leucite-containing ceramics, zirconia-based ceramics; resorbable 3-D ceramic scaffolds for bone tissue replacement.
Primary researcher: Satheesh Elangovan
Developing and testing biomaterials for the purpose of periodontal and bone tissue engineering. Other interests include studying the interactions between biomaterials and biomolecules such as proteins, as well as DNA.
Primary researcher: Julie A. Holloway
Dental ceramics and dental implant materials sciences.
Primary researcher: Liu Hong
Adult stem cell-based craniofacial tissue engineering, including stem cell biology, in vitro and in vivo bone, cartilage and adipose regeneration, MR monitoring of engineered tissues.
Primary researcher: Georgia Johnson
Effects of tobacco products on periodontal host response and the impact of smoking on periodontal treatment outcomes; the role of naturally occurring antimicrobial peptides in periodontal disease and clinical dental implant research.
Primary researcher: John Keller
Biological responses to biomedical materials, especially implants and bone substitute materials; characteristics of implant surfaces; mechanics of implant retention.
Primary researcher: Galen Schneider
Bone cell biology as it relates to implant osseointegration and bone tissue engineering. His research interest focus on several questions: 1. How does osteoblast cell adhesion regulate bone growth at the molecular level? 2. Does implant surface microtopography influence osteoblast differentiation? 3. Can bone tissue be engineered using injectable scaffolds? 4. Can three-dimensional environments be used for osseous tissue engineering?
Primary researcher: Clark Stanford
Role of metal oxide surfaces in regulating osteoblastic gene expression; development of standardized culture models for evaluation of biological/biomaterial responses; effects of cytoskeletal pertubation (strain) at physiological levels on cellular and nuclear activities; mechanical development of approaches for creating physiological levels of strain; role of non-collagenous proteins in altering the temporal and spatial formation of a mineralizing extracellular matrix; evaluation of steady state message for bone related proteins using linear PCR amplification of a CRNA first strand pool derived from osteoblastic cells; the transduction cascade mechanisms involved in regulating mineralization; relationship between dynamic stress loading from dental and orthopaedic implant systems and cortical strain responses as a function of loading parameters, cortical bone properties and framework design; clinical outcomes assessment of dental implant treatment; and computer simulation of learned tactile responses and studies for developing a robotic force feedback teaching and clinical outcomes evaluation.
Primary researcher: Marcos Vargas
Dental materials: glass ionomers, dentin bonding, composite resins and esthetic dentistry.