Dr. Squier joined the College of Dentistry in 1975. He is a professor in the Department of Oral Pathology, Radiology and Medicine, and in the Iowa Institute of Oral Health Research. Dr. Squier is also director of graduate studies at the College of Dentistry, and since 2007, he has been director of Global Health Studies at the University of Iowa.
Dr. Squier teaches undergraduate students and predoctoral and postdoctoral dental students.
For over twenty-five years, Dr. Squier's research has focused on the structure and function of stratified squamous mucosae, with particular regard to the nature of the superficial permeability barrier structure and the role of topical carcinogens and micro-organisms in the pathogenesis of local and systemic disease. Specific areas of interest have been interactions between alcohol and tobacco components in the development of oral cancer and the mechanisms by which Staphylococcae and their toxins are involved in the vaginal pathogenesis of toxic shock syndrome. More recently, he has been concerned with the role of oral health professionals in assisting their patients with tobacco cessation. Dr. Squier has published more than 200 books, chapters, and peer-reviewed articles.
1: Davis CC, Baccam M, Mantz MJ, Osborn TW, Hill DR, Squier CA. Use of porcine vaginal tissue ex-vivo to model environmental effects on vaginal mucosa to toxic shock syndrome toxin-1. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):240-8. doi: 10.1016/j.taap.2013.11.021. Epub 2013 Dec 10. PubMed PMID: 24333258.
2: Sheffer MA, Squier CA, Gilmore GD. Restaurant volatility and the Iowa City, Iowa, smoke-free restaurant ordinance. Am J Health Promot. 2013 Jan-Feb;27(3):177-80. doi: 10.4278/ajhp.07082488. PubMed PMID: 23286594.
3: Kidwai FK, Liu H, Toh WS, Fu X, Jokhun DS, Movahednia MM, Li M, Zou Y, Squier CA, Phan TT, Cao T. Differentiation of human embryonic stem cells into clinically amenable keratinocytes in an autogenic environment. J Invest Dermatol. 2013 Mar;133(3):618-28. doi: 10.1038/jid.2012.384. Epub 2012 Dec 13. PubMed PMID: 23235526.
4: Pendharkar B, Levy SM, McQuistan MR, Qian F, Squier CA, Slach NA, Aquilino ML. Fourth-year dental students' perceived barriers to providing tobacco intervention services. J Dent Educ. 2010 Oct;74(10):1074-85. PubMed PMID: 20930238.
5: Squier CA, Mantz MJ, Wertz PW. Effect of menthol on the penetration of tobacco carcinogens and nicotine across porcine oral mucosa ex vivo. Nicotine Tob Res. 2010 Jul;12(7):763-7. doi: 10.1093/ntr/ntq084. Epub 2010 May 28. PubMed PMID: 20511349.
6: Brosnahan AJ, Mantz MJ, Squier CA, Peterson ML, Schlievert PM. Cytolysins augment superantigen penetration of stratified mucosa. J Immunol. 2009 Feb 15;182(4):2364-73. doi: 10.4049/jimmunol.0803283. PubMed PMID: 19201891; PubMed Central PMCID: PMC2805182.
7: Brosnahan AJ, Schaefers MM, Amundson WH, Mantz MJ, Squier CA, Peterson ML, Schlievert PM. Novel toxic shock syndrome toxin-1 amino acids required for biological activity. Biochemistry. 2008 Dec 9;47(49):12995-3003. doi: 10.1021/bi801468w. PubMed PMID: 19012411; PubMed Central PMCID: PMC2645936.
8: Squier CA, Mantz MJ, Schlievert PM, Davis CC. Porcine vagina ex vivo as a model for studying permeability and pathogenesis in mucosa. J Pharm Sci. 2008 Jan;97(1):9-21. Review. PubMed PMID: 17721937.
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Dr. Squier is an honorary member of the Hungarian Dental Association, a member of the International Association for Dental Research, the Institute of Biology (London, England), the International Society for Stereology, the British Society for Oral Pathology, the International Association of Oral Pathologists, and the Heartland Global Health Consortium.